Epithelial-mesenchymal plasticity and circulating tumor cells: Travel companions to metastases.
Identifieur interne : 000D15 ( Main/Exploration ); précédent : 000D14; suivant : 000D16Epithelial-mesenchymal plasticity and circulating tumor cells: Travel companions to metastases.
Auteurs : Marie-Emilie Francart [Belgique] ; Justine Lambert [Belgique] ; Aline M. Vanwynsberghe [Belgique] ; Erik W. Thompson [Australie] ; Morgane Bourcy [Belgique] ; Myriam Polette [France] ; Christine Gilles [Belgique]Source :
- Developmental dynamics : an official publication of the American Association of Anatomists [ 1097-0177 ] ; 2017.
Abstract
Epithelial-mesenchymal transitions (EMTs) associated with metastatic progression may contribute to the generation of hybrid phenotypes capable of plasticity. This cellular plasticity would provide tumor cells with an increased potential to adapt to the different microenvironments encountered during metastatic spread. Understanding how EMT may functionally equip circulating tumor cells (CTCs) with an enhanced competence to survive in the bloodstream and niche in the colonized organs has thus become a major cancer research axis. We summarize here clinical data with CTC endpoints involving EMT. We then review the work functionally linking EMT programs to CTC biology and deciphering molecular EMT-driven mechanisms supporting their metastatic competence. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc.
DOI: 10.1002/dvdy.24506
PubMed: 28407379
Affiliations:
- Australie, Belgique, France
- Champagne-Ardenne, Grand Est, Province de Liège, Région wallonne, Victoria (État)
- Liège, Melbourne, Reims
- Université de Liège
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This cellular plasticity would provide tumor cells with an increased potential to adapt to the different microenvironments encountered during metastatic spread. Understanding how EMT may functionally equip circulating tumor cells (CTCs) with an enhanced competence to survive in the bloodstream and niche in the colonized organs has thus become a major cancer research axis. We summarize here clinical data with CTC endpoints involving EMT. We then review the work functionally linking EMT programs to CTC biology and deciphering molecular EMT-driven mechanisms supporting their metastatic competence. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li></country><region><li>Champagne-Ardenne</li><li>Grand Est</li><li>Province de Liège</li><li>Région wallonne</li><li>Victoria (État)</li></region><settlement><li>Liège</li><li>Melbourne</li><li>Reims</li></settlement><orgName><li>Université de Liège</li></orgName></list><tree><country name="Belgique"><region name="Région wallonne"><name sortKey="Francart, Marie Emilie" sort="Francart, Marie Emilie" uniqKey="Francart M" first="Marie-Emilie" last="Francart">Marie-Emilie Francart</name></region><name sortKey="Bourcy, Morgane" sort="Bourcy, Morgane" uniqKey="Bourcy M" first="Morgane" last="Bourcy">Morgane Bourcy</name><name sortKey="Gilles, Christine" sort="Gilles, Christine" uniqKey="Gilles C" first="Christine" last="Gilles">Christine Gilles</name><name sortKey="Lambert, Justine" sort="Lambert, Justine" uniqKey="Lambert J" first="Justine" last="Lambert">Justine Lambert</name><name sortKey="Vanwynsberghe, Aline M" sort="Vanwynsberghe, Aline M" uniqKey="Vanwynsberghe A" first="Aline M" last="Vanwynsberghe">Aline M. Vanwynsberghe</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Thompson, Erik W" sort="Thompson, Erik W" uniqKey="Thompson E" first="Erik W" last="Thompson">Erik W. Thompson</name></region></country><country name="France"><region name="Grand Est"><name sortKey="Polette, Myriam" sort="Polette, Myriam" uniqKey="Polette M" first="Myriam" last="Polette">Myriam Polette</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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